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PGD and NGS- based PGS

Pre-implantation genetic diagnosis (PGD)

Pre-implantation genetic diagnosis (PGD) is a technique which makes it possible to detect diseases and defects that a child may inherit from its parents. It offers a chance to all couples at risk of passing on genetic disorders to their children.

What is PGD?


PGD is a form of prenatal genetic diagnosis. It makes it possible to detect or exclude very early a large number of diseases, including the Patau syndrome, Down’s syndrome, Edwards’ syndrome, Klinefelter syndrome and Turner’s syndrome as well as cystic fibrosis, sickle cell anaemia, spinal muscular atrophy, Huntington's disease and haemophilia.

The effectiveness of PGD in detecting defects depends on how many chromosomes are tested for abnormalities. Therefore, InviMed cooperates with the Igenomix Laboratory in Valencia, a European leader in genetic diagnostics. A specialist team of excellent embryologists carries out PGD tests on the set of 22 pairs of chromosomes and the X and Y chromosomes. Test results are available 24 hours after a sample is delivered to the laboratory.

InviMed is the only clinic in Poland to offer such advanced PGD testing. The quality of the tests offered by the clinic is incomparable with the quality of other tests offered in Poland.

Indications for PGD

  • a history of recurrent miscarriages due to genetic diseases,
  • a history of recurrent failures after IVF,
  • significantly damaged sperm,
  • couples who already have a child suffering from a genetic disease,
  • a family history of genetic disorders,
  • chromosomal translocation, i.e. rearrangement of parts between chromosomes, which may cause problems with embryo implantation, recurrent miscarriages, psychological or physical problems in a child, revealed by earlier tests,
  • patients who are carriers of such conditions as: cystic fibrosis, sickle cell anaemia, Tay-Sachs disease, dwarfism and Huntington’s disease.

How does PGD work?


PGD is carried out on embryos during an IVF cycle.

1. Embryo biopsy

Embryos are collected for testing 72-76 hours after fertilisation, when they are at the 6-8 cell stage. This procedure requires high precision and is performed by the most experienced embryologists. After the biopsy, embryos are returned to the incubator so that they may continue to develop. The biopsy of an embryo cell does not affect the proper development of the embryo. The risk that the embryo will stop developing after the biopsy is 0.53%.

2. Genetic diagnosis

Cells obtained by biopsy are prepared for analysis and subjected to genetic testing.

3. Embryo transfer

Embryo transfer takes place immediately after the results of the genetic analysis are obtained, usually 4 or 5 days after the egg collection.

 

NGS-based pre-implantation genetic screening

NGS-based pre-implantation genetic screening is the latest technique which makes it possible to detect an abnormal number of chromosomes based on an examination of a single cell. Recent studies indicate that PGS improves chances for pregnancy in 55-70% of cases.

When should NGS-based PGS be carried out?


It is recommended for patients of advanced age who have a history of recurrent embryo implantation failures and miscarriages. It is also recommended for couples with severe male factor infertility.

How does NGS-based PGS work?


The testing is carried out on embryos during an IVF cycle. 

1. Embryo biopsy

Embryos are collected for testing 72-76 hours after fertilisation, when they are at the 6-8 cell stage. This procedure requires high precision and is performed by the most experienced embryologists. After the biopsy, embryos are returned to the incubator so that they may continue to develop. 

The biopsy of an embryo cell does not affect the proper development of the embryo. The risk that the embryo will stop developing after the biopsy is 0.53%.

2. Genetic diagnosis

Cells obtained by biopsy are prepared for analysis and subjected to genetic testing.

3. Embryo transfer

Embryo transfer takes place immediately after the results of the genetic analysis are obtained, usually 4 or 5 days after the egg collection.

Affordable Excellence

Choose from:

NGS- based PGS up to 4 embryos 7800 PLN (£1635*)
NGS- based PGS 5-9 embryos 9650 PLN (£2023*)
PGD test 11270 - 16570 PLN (£2362 - £3473*)
*For the latest rates in British pounds (GBP) Click here

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130+ international couples choose InviMed each year

I love doing what I’m good at. But, the fact that I’m bringing joy into people’s lives makes me love it even more.
dr-n-med-beata-makowska-invimed-gdynia.jpgBeata Makowska, M.D., Ph.D.

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