PICSI® (Physiological Intracytoplasmic Sperm Injection)
PICSI® fertilization is a technique that uses the physiological properties of mature and properly constructed sperm cells enabling their binding to hyaluronic acid through the presence of hyaluronate receptors on the sperm cell head surface.
In this method, the sperm cells are selected on the basis of morphological criteria as well as positive and specific reaction of binding a sperm cell to hyaluronate.
Normal, moving spermatozoa react with hyaluronate through specific receptors present on their heads. The binding of a sperm cell to hyaluronate suggests that the selected sperm cell has correctly undergone the whole spermatogenesis process, is biologically mature, fully functional and competent for fertilising the egg cell.
The male gametes selected during the PICSI® procedure increase the probability of egg fertilization and subsequent correct embryo development.
According to current research, the use of the PICSI® technique, compared to the standard ICSI procedure, statistically increases the percentage of fertilization of egg cells and allows to obtain a higher percentage of high quality embryos and the chance of pregnancy.
In vitro fertilization using the PICSI® method is recommended in the case of couples:
- have experienced recurrent miscarriages,
- in which the men obtained a SCD, MSOME and HBA test result out of the range of normal,
- whose attempt the ICSI procedure using frozen semen with low parameters or sperm cell suspension obtained by TESA, PESA, or MESA,
- they have failed to get pregnant with the help of standard in vitro or ICSI (few developing embryos and embryos of poor quality, difficulties in embryo implantation despite taking medicines),
- who have sperm cells with severe asthenozoospermia or a very low percentage of sperm cells of normal morphology (the so-called severe teratozoospermia).